Autoradiographic Studies on Turnover Time and Protein Synthesis in Pig Epidermis.

The epidermis undergoes constant cellular renewal at the basal cell layer to replace the continual loss of cells by the stratum corneum. Leblond and Walker (1) reviewed studies on turnover timest of normal epidermis and found that they ranged from 13—100 days in different mammals. Recently, Rothberg, et at (2) determined the turnover time of human epidermis by measuring isotopically labeled stratum corneum protein (keratin) collected after the intravenous injection of glycine-C14. They reported a turnover time of normal epidermis to